Update 2008-08-22: This page has received a large amount of traffic from people looking for implementations of the Blueprint CSS theme project. Here are some links to help out those people:
Original content: I finally moved away from the generic Drupal "garland" template today. This new "blueprint" design started as an outline for something much more complicated, but I liked it so much I decided to put it up. I plan to make subtle alterations to the template over time, so look forward to little surprises.